Reaction Details |
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Target | Secreted frizzled-related protein 1 |
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Ligand | BDBM50265548 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_560813 (CHEMBL1011781) |
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IC50 | 90±n/a nM |
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Citation | Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem52:105-16 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Secreted frizzled-related protein 1 |
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Name: | Secreted frizzled-related protein 1 |
Synonyms: | FRP | FRP1 | SARP2 | SFRP1 | SFRP1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 35404.91 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1363191 |
Residue: | 314 |
Sequence: | MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVD
IPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPV
CLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKP
QGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKK
KDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKK
MKNHECPTFQSVFK
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BDBM50265548 |
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n/a |
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Name | BDBM50265548 |
Synonyms: | CHEMBL501332 | N-[1-(N,N-Dimethylglycyl-L-prolyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide |
Type | Small organic molecule |
Emp. Form. | C27H33F3N4O6S2 |
Mol. Mass. | 630.699 |
SMILES | CN(C)CC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r| |
Structure |
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