| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
|---|
| Ligand | BDBM50247847 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_495250 (CHEMBL1003656) |
|---|
| IC50 | 40±n/a nM |
|---|
| Citation |  Scholz, M; Ulbrich, HK; Soehnlein, O; Lindbom, L; Mattern, A; Dannhardt, G Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem17:558-68 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin G/H synthase 1 |
|---|
| Name: | Prostaglandin G/H synthase 1 |
|---|
| Synonyms: | COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | PGH1_BOVIN | PTGS1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 68814.10 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_547440 |
|---|
| Residue: | 600 |
|---|
| Sequence: | MSRQGISLRFPLLLLLLSPSPVLPADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCT
RTGYYGPNCTIPEIWTWLRTTLRPSPSFVHFLLTHGRWLWDFVNATFIRDKLMRLVLTVR
SNLIPSPPTYNVAHDYISWESFSNVSYYTRILPSVPRDCPTPMGTKGKKQLPDAEFLSRR
FLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLER
QYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMV
YATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLK
FDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVE
ALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRELRLQPFNEYRKRFGMKPYTSFQE
LTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPIC
SPEYWKASTFGGDVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPHREDRPGVERPPTEL
|
|
|
|---|
| BDBM50247847 |
|---|
| n/a |
|---|
| Name | BDBM50247847 |
|---|
| Synonyms: | 5-(4-Chlorophenyl)-4-p-tolylisothiazole | CHEMBL524133 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H12ClNS |
|---|
| Mol. Mass. | 285.791 |
|---|
| SMILES | Cc1ccc(cc1)-c1cnsc1-c1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
