| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonyl reductase [NADPH] 1 |
|---|
| Ligand | BDBM50247677 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_495288 (CHEMBL1004505) |
|---|
| IC50 | 210±n/a nM |
|---|
| Citation |  Zimmermann, TJ; Niesen, FH; Pilka, ES; Knapp, S; Oppermann, U; Maier, ME Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone. Bioorg Med Chem17:530-6 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonyl reductase [NADPH] 1 |
|---|
| Name: | Carbonyl reductase [NADPH] 1 |
|---|
| Synonyms: | CBR | CBR1 | CBR1_HUMAN | CRN | SDR21C1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 30380.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_607770 |
|---|
| Residue: | 277 |
|---|
| Sequence: | MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
|
|
|
|---|
| BDBM50247677 |
|---|
| n/a |
|---|
| Name | BDBM50247677 |
|---|
| Synonyms: | (3S,8S)-14,16-dihydroxy-3,8-dimethyl-3,4,5,6,9,10-hexahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione | CHEMBL453375 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H24O5 |
|---|
| Mol. Mass. | 332.3909 |
|---|
| SMILES | C[C@H]1CCCC(=O)[C@@H](C)CC\C=C\c2cc(O)cc(O)c2C(=O)O1 |r,t:11| |
|---|
| Structure | 
|
|---|
Search and Browse
