| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonyl reductase [NADPH] 1 |
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| Ligand | BDBM50096619 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_495288 (CHEMBL1004505) |
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| IC50 | 3780±n/a nM |
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| Citation |  Zimmermann, TJ; Niesen, FH; Pilka, ES; Knapp, S; Oppermann, U; Maier, ME Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone. Bioorg Med Chem17:530-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonyl reductase [NADPH] 1 |
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| Name: | Carbonyl reductase [NADPH] 1 |
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| Synonyms: | CBR | CBR1 | CBR1_HUMAN | CRN | SDR21C1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30380.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_607770 |
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| Residue: | 277 |
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| Sequence: | MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
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| BDBM50096619 |
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| n/a |
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| Name | BDBM50096619 |
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| Synonyms: | 1,8,9-Trihydroxy-3-methoxy-benzo[4,5]furo[3,2-c]chromen-6-one | 7-methoxy-5,11,12-trihydroxy-coumestan | CHEMBL97453 | Wedelolactone |
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| Type | Small organic molecule |
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| Emp. Form. | C16H10O7 |
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| Mol. Mass. | 314.2464 |
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| SMILES | COc1cc(O)c2c3oc4cc(O)c(O)cc4c3c(=O)oc2c1 |
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| Structure | 
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