Reaction Details |
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Target | Histone deacetylase 8 |
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Ligand | BDBM50255854 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_515268 (CHEMBL991292) |
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IC50 | 1150±n/a nM |
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Citation | Smil, DV; Manku, S; Chantigny, YA; Leit, S; Wahhab, A; Yan, TP; Fournel, M; Maroun, C; Li, Z; Lemieux, AM; Nicolescu, A; Rahil, J; Lefebvre, S; Panetta, A; Besterman, JM; Déziel, R Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. Bioorg Med Chem Lett19:688-92 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 8 |
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Name: | Histone deacetylase 8 |
Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
Type: | Enzyme |
Mol. Mass.: | 41749.60 |
Organism: | Homo sapiens (Human) |
Description: | Q9BY41 |
Residue: | 377 |
Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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BDBM50255854 |
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n/a |
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Name | BDBM50255854 |
Synonyms: | (R)-tert-butyl 4-(1-(4-(hydroxycarbamoyl)benzyl)-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)butylcarbamate | CHEMBL480729 |
Type | Small organic molecule |
Emp. Form. | C25H32N4O5 |
Mol. Mass. | 468.5454 |
SMILES | CC(C)(C)OC(=O)NCCCC[C@H]1N(Cc2ccc(cc2)C(=O)NO)c2ccccc2NC1=O |r| |
Structure |
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