Reaction Details |
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Target | P2X purinoceptor 3 |
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Ligand | BDBM50413360 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_562361 (CHEMBL1017975) |
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IC50 | 63±n/a nM |
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Citation | Jahangir, A; Alam, M; Carter, DS; Dillon, MP; Bois, DJ; Ford, AP; Gever, JR; Lin, C; Wagner, PJ; Zhai, Y; Zira, J Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett19:1632-5 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 3 |
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Name: | P2X purinoceptor 3 |
Synonyms: | ATP receptor | P2RX3_RAT | P2X purinoceptor 3 | P2X3 | P2rx3 | Purinergic receptor | ratp2x3 | ratp2x3 + rsa |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 44397.63 |
Organism: | RAT |
Description: | Purinergic, P2X3 0 RAT::P49654 |
Residue: | 397 |
Sequence: | MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKYRCVSDS
QCGPERFPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVEMPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTDKDIKRCRFHPEKAPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEE
VTETTLKGTASTNPVFASDQATVEKQSTDSGAYSIGH
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BDBM50413360 |
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n/a |
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Name | BDBM50413360 |
Synonyms: | CHEMBL492745 |
Type | Small organic molecule |
Emp. Form. | C20H29IN6O2 |
Mol. Mass. | 512.3877 |
SMILES | COc1cc(C(C)C)c(Oc2cnc(NCCN3CCNCC3)nc2N)cc1I |
Structure |
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