| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acyl-CoA (8-3)-desaturase |
|---|
| Ligand | BDBM50258197 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_562700 (CHEMBL1012735) |
|---|
| IC50 | >30±n/a nM |
|---|
| Citation |  Koltun, DO; Parkhill, EQ; Vasilevich, NI; Glushkov, AI; Zilbershtein, TM; Ivanov, AV; Cole, AG; Henderson, I; Zautke, NA; Brunn, SA; Mollova, N; Leung, K; Chisholm, JW; Zablocki, J Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett19:2048-52 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acyl-CoA (8-3)-desaturase |
|---|
| Name: | Acyl-CoA (8-3)-desaturase |
|---|
| Synonyms: | FADS1_RAT | Fads1 | Fatty acid desaturase 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52505.96 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_852948 |
|---|
| Residue: | 447 |
|---|
| Sequence: | MAPDPVQTPDPASAQLRQMRYFTWEEVAQRSGREKERWLVIDRKVYNISDFSRRHPGGSR
VISHYAGQDATDPFVAFHINKGLVRKYMNSLLIGELAPEQPSFEPTKNKALTDEFRELRA
TVERMGLMKANHLFFLFYLLHILLLDVAAWLTLWIFGTSLVPFTLCAVLLSTVQAQAGWL
QHDFGHLSVFSTSTWNHLVHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPL
FFALGKVLSVELGKEKKKHMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVVQRKKWVDLA
WMLSFYVRVFFTYMPLLGLKGLLCLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNVDWVS
TQLQATCNVHQSAFNNWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKYGIKYESK
PLLTAFADIVYSLKESGQLWLDAYLHQ
|
|
|
|---|
| BDBM50258197 |
|---|
| n/a |
|---|
| Name | BDBM50258197 |
|---|
| Synonyms: | CHEMBL495191 | N-(2-(6-(3,4-dichlorobenzylamino)-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl)ethyl)acetamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H23Cl2N5O3 |
|---|
| Mol. Mass. | 512.388 |
|---|
| SMILES | COc1ccc(cc1)-c1nc2ccc(NCc3ccc(Cl)c(Cl)c3)nc2n(CCNC(C)=O)c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
