| Reaction Details |
|---|
 | Report a problem with these data |
| Target | NH(3)-dependent NAD(+) synthetase |
|---|
| Ligand | BDBM50278416 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_564355 (CHEMBL957657) |
|---|
| IC50 | 186000±n/a nM |
|---|
| Citation |  Moro, WB; Yang, Z; Kane, TA; Brouillette, CG; Brouillette, WJ Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs). Bioorg Med Chem Lett19:2001-5 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| NH(3)-dependent NAD(+) synthetase |
|---|
| Name: | NH(3)-dependent NAD(+) synthetase |
|---|
| Synonyms: | BAS1855 | BA_1998 | GBAA_1998 | NADE_BACAN | Nicotinamide adenine dinucleotide synthetase (NADs) | nadE |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 30092.16 |
|---|
| Organism: | Bacillus anthracis |
|---|
| Description: | Q81RP3 |
|---|
| Residue: | 272 |
|---|
| Sequence: | MTLQEQIMKALHVQPVIDPKAEIRKRVDFLKDYVKKTGAKGFVLGISGGQDSTLAGRLAQ
LAVEEIRNEGGNATFIAVRLPYKVQKDEDDAQLALQFIQADQSVAFDIASTVDAFSNQYE
NLLDESLTDFNKGNVKARIRMVTQYAIGGQKGLLVIGTDHAAEAVTGFFTKFGDGGADLL
PLTGLTKRQGRALLQELGADERLYLKMPTADLLDEKPGQADETELGITYDQLDDYLEGKT
VPADVAEKIEKRYTVSEHKRQVPASMFDDWWK
|
|
|
|---|
| BDBM50278416 |
|---|
| n/a |
|---|
| Name | BDBM50278416 |
|---|
| Synonyms: | 2-(3-(3-nitrobenzoyl)thioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide | CHEMBL469773 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H16N4O4S2 |
|---|
| Mol. Mass. | 404.463 |
|---|
| SMILES | NC(=O)c1c(NC(=S)NC(=O)c2cccc(c2)[N+]([O-])=O)sc2CCCCc12 |
|---|
| Structure | 
|
|---|
Search and Browse
