| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cathepsin B |
|---|
| Ligand | BDBM50257017 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_562602 (CHEMBL1016183) |
|---|
| Ki | 850±n/a nM |
|---|
| Citation |  Ettari, R; Micale, N; Schirmeister, T; Gelhaus, C; Leippe, M; Nizi, E; Di Francesco, ME; Grasso, S; Zappalà, M Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors. J Med Chem52:2157-60 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cathepsin B |
|---|
| Name: | Cathepsin B |
|---|
| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 37819.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_63102437 |
|---|
| Residue: | 339 |
|---|
| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
|
|
|
|---|
| BDBM50257017 |
|---|
| n/a |
|---|
| Name | BDBM50257017 |
|---|
| Synonyms: | (4-Chloro-2-trifluoromethyl-phenyl)-carbamic acid 1-[(3-dimethylcarbamoylallylcarbamoyl)-methyl]-(3R)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl ester | CHEMBL450218 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H29ClF3N5O5 |
|---|
| Mol. Mass. | 656.051 |
|---|
| SMILES | CN(C)C(=O)\C=C\CNC(=O)CN1c2ccccc2C(=N[C@H](COC(=O)Nc2ccc(Cl)cc2C(F)(F)F)C1=O)c1ccccc1 |r,c:20| |
|---|
| Structure | 
|
|---|
Search and Browse
