Reaction Details |
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Target | Sodium- and chloride-dependent glycine transporter 1 |
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Ligand | BDBM50277866 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_501634 (CHEMBL993724) |
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IC50 | 0.100000±n/a nM |
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Citation | Thomson, JL; Blackaby, WP; Jennings, AS; Goodacre, SC; Pike, A; Thomas, S; Brown, TA; Smith, A; Pillai, G; Street, LJ; Lewis, RT Optimisation of a series of potent, selective and orally bioavailable GlyT1 inhibitors. Bioorg Med Chem Lett19:2235-9 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent glycine transporter 1 |
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Name: | Sodium- and chloride-dependent glycine transporter 1 |
Synonyms: | GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9 |
Type: | Enzyme |
Mol. Mass.: | 78270.54 |
Organism: | Homo sapiens (Human) |
Description: | P48067 |
Residue: | 706 |
Sequence: | MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
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BDBM50277866 |
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n/a |
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Name | BDBM50277866 |
Synonyms: | 2,4-dichloro-N-((3-(cyclopropylmethyl)-1-(1-methyl-1H-1,2,3-triazol-4-ylsulfonyl)azetidin-3-yl)methyl)benzamide | CHEMBL485356 |
Type | Small organic molecule |
Emp. Form. | C18H21Cl2N5O3S |
Mol. Mass. | 458.362 |
SMILES | Cn1cc(nn1)S(=O)(=O)N1CC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CC2)C1 |
Structure |
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