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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Ribosomal protein S6 kinase beta-1 | ||
| Ligand | BDBM50277910 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_501969 (CHEMBL985892) | ||
| IC50 | >30000±n/a nM | ||
| Citation |  Humphries, PS; Lafontaine, JA; Agree, CS; Alexander, D; Chen, P; Do, QQ; Li, LY; Lunney, EA; Rajapakse, RJ; Siegel, K; Timofeevski, SL; Wang, T; Wilhite, DM Synthesis and SAR of 4-substituted-2-aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors. Bioorg Med Chem Lett19:2099-102 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Ribosomal protein S6 kinase beta-1 | |||
| Name: | Ribosomal protein S6 kinase beta-1 | ||
| Synonyms: | 70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | KS6B1_HUMAN | Protein kinase 70S6K (T412E) | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | RPS6KB1 | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase I | S6K1 | STK14A | p70 S6 ribosomal protein kinase 1 | p70S6K1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 59139.89 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | His-tagged S6K1. | ||
| Residue: | 525 | ||
| Sequence: |
| ||
| BDBM50277910 | |||
| n/a | |||
| Name | BDBM50277910 | ||
| Synonyms: | 4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyrazol-3-yl)cyclohexanol | CHEMBL507249 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H25N5O | ||
| Mol. Mass. | 327.424 | ||
| SMILES | O[C@H]1CC[C@@H](CC1)c1[nH]ncc1-c1ccnc(NC2CCCC2)n1 |r,wU:4.7,wD:1.0,(-.62,.56,;.73,1.31,;2.05,.52,;3.4,1.27,;3.42,2.81,;2.09,3.6,;.76,2.85,;4.88,3.29,;5.35,4.76,;6.89,4.76,;7.37,3.3,;6.14,2.4,;6.14,.86,;4.81,.09,;4.81,-1.46,;6.14,-2.23,;7.48,-1.46,;8.82,-2.23,;8.82,-3.77,;7.58,-4.66,;8.05,-6.13,;9.59,-6.12,;10.07,-4.66,;7.48,.09,)| | ||
| Structure | 
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