Ki Summary

Reaction Details

Report a problem with these data

Target

Mitogen-activated protein kinase 8

Ligand

BDBM50277947

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_501722 (CHEMBL985050)

9±n/a nM

Citation

Humphries, PS; Lafontaine, JA; Agree, CS; Alexander, D; Chen, P; Do, QQ; Li, LY; Lunney, EA; Rajapakse, RJ; Siegel, K; Timofeevski, SL; Wang, T; Wilhite, DM Synthesis and SAR of 4-substituted-2-aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors. Bioorg Med Chem Lett19:2099-102 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase 8

Name:

Mitogen-activated protein kinase 8

Synonyms:

Type:

Enzyme

Mol. Mass.:

48297.57

Organism:

Homo sapiens (Human)

Description:

JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).

Residue:

427

Sequence:

MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR

BDBM50277947

n/a

Name

BDBM50277947

Synonyms:

CHEMBL482559 | N-(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyrazol-3-yl)cyclohexyl)methanesulfonamide

Type

Small organic molecule

Emp. Form.

C19H28N6O2S

Mol. Mass.

404.53

SMILES

CS(=O)(=O)N[C@H]1CC[C@@H](CC1)c1[nH]ncc1-c1ccnc(NC2CCCC2)n1 |r,wU:8.11,wD:5.4,(22.41,-2.51,;22.42,-.98,;20.88,-.96,;23.96,-1,;22.44,.56,;23.79,1.31,;25.11,.52,;26.46,1.27,;26.48,2.81,;25.16,3.6,;23.82,2.85,;27.94,3.29,;28.41,4.76,;29.95,4.76,;30.43,3.3,;29.2,2.4,;29.2,.86,;27.87,.09,;27.87,-1.46,;29.21,-2.23,;30.54,-1.46,;31.88,-2.23,;31.88,-3.77,;30.64,-4.66,;31.11,-6.13,;32.66,-6.12,;33.13,-4.66,;30.54,.09,)|

Structure