| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50259003 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_499620 (CHEMBL972418) |
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| Ki | 7.7±n/a nM |
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| Citation |  Grosse Maestrup, E; Wiese, C; Schepmann, D; Hiller, A; Fischer, S; Scheunemann, M; Brust, P; Wünsch, B Synthesis of spirocyclic sigma1 receptor ligands as potential PET radiotracers, structure-affinity relationships and in vitro metabolic stability. Bioorg Med Chem17:3630-41 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
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| Type: | Protein |
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| Mol. Mass.: | 25307.17 |
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| Organism: | Cavia porcellus (Guinea pig) |
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| Description: | Q60492 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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| BDBM50259003 |
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| n/a |
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| Name | BDBM50259003 |
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| Synonyms: | 1'-(4-Fluorobenzyl)spiro[[2]benzofuran-1,4'-piperidin]-3-one | 1'-(4-fluorobenzyl)-3H-spiro[isobenzofuran-1,4'-piperidin]-3-one | CHEMBL513470 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18FNO2 |
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| Mol. Mass. | 311.3501 |
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| SMILES | Fc1ccc(CN2CCC3(CC2)OC(=O)c2ccccc32)cc1 |
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| Structure | 
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