| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-carbonic anhydrase 1 |
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| Ligand | BDBM50258587 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_519733 (CHEMBL938996) |
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| Ki | 9±n/a nM |
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| Citation |  Güzel, O; Maresca, A; Scozzafava, A; Salman, A; Balaban, AT; Supuran, CT Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273. J Med Chem52:4063-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-carbonic anhydrase 1 |
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| Name: | Beta-carbonic anhydrase 1 |
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| Synonyms: | β-Carbonic anhydrase 1 (CA 1) | Carbonic Anhydrase (mtCA 1) | MTCA1_MYCTU | Uncharacterized protein Rv1284/MT1322 | canA | mtcA1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 18186.06 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | The recombinant GST-mtCA1 construct was cloned, expressed, and further purified from E. coli. The purified protein was used in inhibition assays. |
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| Residue: | 163 |
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| Sequence: | MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRMLGIKEGEAHVIRNAG
CVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRAIQDETGIRPTWSPESY
PDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP
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| BDBM50258587 |
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| n/a |
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| Name | BDBM50258587 |
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| Synonyms: | 1-(([5-(Aminosulfonyl)-3-phenyl-1H-indol-2-yl]carbonyl)amino)-2,4,6-trimethylpyridinium Perchlorate | 2,4,6-trimethyl-1-(3-phenyl-5-sulfamoyl-1H-indole-2-carboxamido)pyridinium perchlorate | CHEMBL466832 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23N4O3S |
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| Mol. Mass. | 435.518 |
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| SMILES | Cc1cc(C)[n+](NC(=O)c2[nH]c3ccc(cc3c2-c2ccccc2)S(N)(=O)=O)c(C)c1 |
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| Structure | 
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