Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50258369 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_522840 (CHEMBL1002508) |
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IC50 | 8±n/a nM |
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Citation | Kinzel, O; Llauger-Bufi, L; Pescatore, G; Rowley, M; Schultz-Fademrecht, C; Monteagudo, E; Fonsi, M; Gonzalez Paz, O; Fiore, F; Steinkühler, C; Jones, P Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties. J Med Chem52:3453-6 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50258369 |
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n/a |
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Name | BDBM50258369 |
Synonyms: | (S)-1-methyl-N-(7-oxo-1-(5-(quinoxalin-2-yl)-1H-imidazol-2-yl)octyl)azetidine-3-carboxamide | CHEMBL2448572 |
Type | Small organic molecule |
Emp. Form. | C25H32N6O2 |
Mol. Mass. | 448.5606 |
SMILES | CCC(=O)CCCCC[C@H](NC(=O)C1CN(C)C1)c1ncc([nH]1)-c1cnc2ccccc2n1 |r| |
Structure |
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