| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Gastrin-releasing peptide receptor |
|---|
| Ligand | BDBM50279042 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_545065 (CHEMBL1017181) |
|---|
| IC50 | 1.45±n/a nM |
|---|
| Citation |  Gourni, E; Bouziotis, P; Benaki, D; Loudos, G; Xanthopoulos, S; Paravatou-Petsotas, M; Mavri-Vavagianni, M; Pelecanou, M; Archimandritis, SC; Varvarigou, AD Structural assessment and biological evaluation of two N3S bombesin derivatives. J Med Chem52:4234-46 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Gastrin-releasing peptide receptor |
|---|
| Name: | Gastrin-releasing peptide receptor |
|---|
| Synonyms: | Bombesin 2 | GRP-R | GRP-preferring bombesin receptor | GRPR | GRPR_HUMAN | Gastrin releasing peptide receptor | Gastrin-releasing peptide receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 43214.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Bombesin 2 GRPR 0::P30550 |
|---|
| Residue: | 384 |
|---|
| Sequence: | MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNIT
LIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQ
LTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSD
LHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQS
AYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLH
FVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTS
LKSTNPSVATFSLINGNICHERYV
|
|
|
|---|
| BDBM50279042 |
|---|
| n/a |
|---|
| Name | BDBM50279042 |
|---|
| Synonyms: | (2S)-N1-((5S,8S,11S,17S,20S,23S)-11-((1H-imidazol-5-yl)methyl)-5-carbamoyl-24-(1H-indol-3-yl)-8-isobutyl-17-isopropyl-20-methyl-7,10,13,16,19,22-hexaoxo-2-thia-6,9,12,15,18,21-hexaazatetracosan-23-yl)-2-(6-(2-(2-(2-aminoacetamido)acetamido)-3-mercaptopropanamido)hexanamido)pentanediamide | CHEMBL505216 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C56H87N17O13S2 |
|---|
| Mol. Mass. | 1270.526 |
|---|
| SMILES | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)CCCCCNC(=O)C(CS)NC(=O)CNC(=O)CN)C(C)C)C(N)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
