Reaction Details |
| Report a problem with these data |
Target | Prostaglandin G/H synthase 1/2 |
---|
Ligand | BDBM22971 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_217529 (CHEMBL819590) |
---|
IC50 | 100±n/a nM |
---|
Citation | Boschelli, DH; Connor, DT; Kuipers, PJ; Wright, CD Synthesis and cyclooxygenase and 5-lipoxygenase inhibitory activity of some thiazolidene-4-one analogs of meclofenamic acid Bioorg Med Chem Lett2:705-708 (1992) Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Prostaglandin G/H synthase 1/2 |
---|
Name: | Prostaglandin G/H synthase 1/2 |
Synonyms: | Cyclooxygenase |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 1666355 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Prostaglandin G/H synthase 2 |
Synonyms: | Cox-2 | Cox2 | Cyclooxygenase | PGH2_RAT | Ptgs2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 69173.51 |
Organism: | RAT |
Description: | COX-2 0 RAT::P35355 |
Residue: | 604 |
Sequence: | MLFRAVLLCAALALSHAANPCCSNPCQNRGECMSIGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRNSIMRYVLTSRSHLIDSPPTYNVHY
GYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGT
NMMFAFFAQHFTHQFFKTDQKRGPGFTRGLGHGVDLNHVYGETLDRQHKLRLFQDGKLKY
QVIGGEVYPPTVKDTQVDMIYPPHVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
ILKQEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIASEFNTLYHWHPLLPDTFNIEDQEYTFKQFLYNNSILLEHGLAHFVESFTRQIAGRV
AGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKAL
YHDIDAMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEV
GFRIINTASIQSLICNNVKGCPFASFNVQDPQPTKTATINASASHSRLDDINPTVLIKRR
STEL
|
|
|
Component 2 |
Name: | Prostaglandin G/H synthase 1 |
Synonyms: | Cox-1 | Cox1 | Cyclooxygenase | Cyclooxygenase-1 | PGH1_RAT | Prostaglandin G/H synthase (cyclooxygenase) | Ptgs1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 69033.56 |
Organism: | RAT |
Description: | COX-1 0 RAT::Q63921 |
Residue: | 602 |
Sequence: | MSRRSLSLQFPLLLLLLLLPPPPVLLTDAGVPSPVNPCCYYPCQNQGVCVRFGLDHYQCD
CTRTGYSGPNCTIPEIWTWLRSSLRPSPSFTHFLLTHGYWIWEFVNATFIREVLMRLVIT
VRSNLIPSPPTYNTAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDIHLLA
QRLLLRREFIPGPQGTNVLFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDSL
ERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPEKQMAVGQEVFGLLPGL
MLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIIIEEYVQHLSGYFLQ
LKFDPELLFRAQFQYRNRIALEFNHLYHWHPLMPDSFQVGSQEYSYEQFLFNTSMLVDYG
VEALVDAFSRQRAGRIGGGRNFDYHVLHVAEDVIKESREMRLQSFNEYRKRFGLKPYTSF
QEFTGEKEMAAELEELYGDIDALEFYPGLMLEKCQPNSLFGESMIEMGAPFSLKGLLGNP
ICSPEYWKPSTFGGDVGFNIVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVFVRPST
EL
|
|
|
BDBM22971 |
---|
n/a |
---|
Name | BDBM22971 |
Synonyms: | 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid | CHEMBL509 | Meclofenamate | Meclofenamic acid | US11337935, Compound Meclofenamic-acid | US20240002326, Compound Meclofenamic acid |
Type | Small organic molecule |
Emp. Form. | C14H11Cl2NO2 |
Mol. Mass. | 296.149 |
SMILES | Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl |
Structure |
|