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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Polyunsaturated fatty acid 5-lipoxygenase | ||
| Ligand | BDBM50281095 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_3839 | ||
| IC50 | 380±n/a nM | ||
| Citation |  Hodgson, ST; Wates, PJ; Blackwell, GJ; Craig, C; Yeadon, M; Boughton-Smith, N Design and synthesis of achiral 5-lipoxygenase inhibitors employing the cyclobutyl group Bioorg Med Chem Lett3:2565-2570 (1993) Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Polyunsaturated fatty acid 5-lipoxygenase | |||
| Name: | Polyunsaturated fatty acid 5-lipoxygenase | ||
| Synonyms: | 5-LO | 5-Lipo-oxygenase (5-LOX) | 5-Lipoxygenase (5-LO) | 5-Lipoxygenase (LOX) | 5-Lipoygenase | 5-lipoxygenase/FLAP | ALOX5 | Arachidonate 5-lipoxygenase | LOG5 | LOX5_HUMAN | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 77972.74 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Recombinant protein was purified from E. coli lysate. After ammonium sulfate precipitation and subsequent steps, the supernatant (S100) was used for 5-LO activity assay. | ||
| Residue: | 674 | ||
| Sequence: |
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| BDBM50281095 | |||
| n/a | |||
| Name | BDBM50281095 | ||
| Synonyms: | CHEMBL405188 | N-[3-(1-benzothien-2-yl)cyclobutyl]-N-hydroxyurea | ||
| Type | Small organic molecule | ||
| Emp. Form. | C13H14N2O2S | ||
| Mol. Mass. | 262.327 | ||
| SMILES | NC(=O)N(O)[C@H]1C[C@@H](C1)c1cc2ccccc2s1 |wU:7.9,wD:5.4,(13.91,-8.94,;12.58,-8.17,;12.58,-6.63,;11.25,-8.94,;11.25,-10.48,;10.17,-7.85,;10.18,-6.31,;8.64,-6.31,;8.63,-7.85,;7.31,-5.54,;6.39,-4.29,;4.93,-4.78,;3.59,-4.01,;2.26,-4.78,;2.26,-6.33,;3.59,-7.1,;4.93,-6.32,;6.4,-6.79,)| | ||
| Structure | 
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