| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Squalene synthase |
|---|
| Ligand | BDBM50281116 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_201958 |
|---|
| IC50 | 7±n/a nM |
|---|
| Citation |  Giblin, GM; Bell, R; Hancock, AP; Hartley, CD; Inglis, GG; Payne, JJ; Procopiou, PA; Shingler, AH; Smith, C; Spooner, SJ Semi-synthetic qualestatins: Squalene synthase inhibition and antifungal activity. The SAR of C6 and C7 modifications Bioorg Med Chem Lett3:2605-2610 (1993) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Squalene synthase |
|---|
| Name: | Squalene synthase |
|---|
| Synonyms: | FDFT1 | FDFT_HUMAN | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | SQS | SS | Squalene synthetase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 48114.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1352847 |
|---|
| Residue: | 417 |
|---|
| Sequence: | MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQA
LDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQ
VLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYV
KKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTR
QIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
|
|
|
|---|
| BDBM50281116 |
|---|
| n/a |
|---|
| Name | BDBM50281116 |
|---|
| Synonyms: | (1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-6-phenyl-hexyl)-4,7-dihydroxy-6-(7-phenyl-heptanoyloxy)-2,8-dioxa-bicyclo[3.2.1]octane-3,4,5-tricarboxylic acid | CHEMBL315074 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C38H46O14 |
|---|
| Mol. Mass. | 726.7634 |
|---|
| SMILES | C[C@H](Cc1ccccc1)[C@H](OC(C)=O)C(=C)CC[C@]12O[C@@]([C@H](OC(=O)CCCCCCc3ccccc3)[C@H]1O)(C(O)=O)[C@@](O)([C@H](O2)C(O)=O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
