| Reaction Details |
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 | Report a problem with these data |
| Target | 3-phosphoshikimate 1-carboxyvinyltransferase |
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| Ligand | BDBM50281993 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_65087 (CHEMBL673144) |
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| Ki | 1500±n/a nM |
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| Citation |  Miller, MJ; Anderson, KS; Braccolino, DS; Cleary, DG; Gruys, KJ; Han, CY; Lin, KC; Pansegrau, PD; Ream, JE; Sammons, RD; Sikorski, JA EPSP synthase inhibitor design II. The importance of the 3-phosphate group for ligand binding at the shikimate-3-phosphate site & the identification of 3-malonate ethers as novel 3-phosphate mimics. Bioorg Med Chem Lett3:1435-1440 (1993) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-phosphoshikimate 1-carboxyvinyltransferase |
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| Name: | 3-phosphoshikimate 1-carboxyvinyltransferase |
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| Synonyms: | 5-enolpyruvylshikimate-3-phosphate synthase | AROA_ECOLI | aroA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46089.22 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | ChEMBL_65087 |
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| Residue: | 427 |
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| Sequence: | MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL
GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR
MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA
PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE
GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE
LNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVE
EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQL
ARISQAA
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| BDBM50281993 |
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| n/a |
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| Name | BDBM50281993 |
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| Synonyms: | CHEMBL287334 | Trisodium salt of (3R,4S,5R)-5-Carboxymethoxy-4-hydroxy-3-phosphonooxy-cyclohex-1-enecarboxylic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C9H10O10P |
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| Mol. Mass. | 309.1451 |
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| SMILES | O[C@H]1[C@@H](CC(=C[C@H]1OP(O)([O-])=O)C([O-])=O)OCC([O-])=O |c:4| |
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| Structure | 
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