Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50282092 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_159319 (CHEMBL769372) |
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IC50 | 70±n/a nM |
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Citation | Trova, MP; Babine, RE; Byrn, RA; Casscles, WT; Hastings, RC; Hsu, GC; Jirousek, MR; Johnson, BD; Kerwar, SS; Schow, SR; Wissner, A; Zhang, N; Wick, MM Synthesis and biological evaluation of a series of HIV-1 protease inhibitors Bioorg Med Chem Lett3:1595-1600 (1993) Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50282092 |
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n/a |
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Name | BDBM50282092 |
Synonyms: | CHEMBL412878 | Isoquinoline-3-carboxylic acid {(1S,2S)-2-[(R)-2-benzyl-5-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-4-hydroxy-pentanoylamino]-cyclohexyl}-amide |
Type | Small organic molecule |
Emp. Form. | C42H57N5O4 |
Mol. Mass. | 695.9331 |
SMILES | CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1CC(O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCCC[C@@H]1NC(=O)c1cc2ccccc2cn1 |
Structure |
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