| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50284050 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_205407 |
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| IC50 | 70.0±n/a nM |
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| Citation |  Achard, A; Truchon, A; Peyronel, JF Perhydrothiopyranopyrroles derivatives : A novel series of potent and selective nonpeptide NK1 antagonists. Bioorg Med Chem Lett4:669-672 (1994) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50284050 |
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| n/a |
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| Name | BDBM50284050 |
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| Synonyms: | (S)-2-(2-Methoxy-phenyl)-1-((R)-1-oxo-4,4-diphenyl-octahydro-1lambda*4*-thiopyrano[2,3-c]pyrrol-6-yl)-propan-1-one | CHEMBL119990 | RP-73467 | RP-73647 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31NO3S |
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| Mol. Mass. | 473.626 |
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| SMILES | COc1ccccc1[C@H](C)C(=O)N1CC2[C@@H](C1)C(CCS2=O)(c1ccccc1)c1ccccc1 |
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| Structure | 
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