| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50284699 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_65795 (CHEMBL677976) |
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| IC50 | 25000±n/a nM |
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| Citation |  Nagase, T; Mase, T; Fukami, T; Hayama, T; Fujita, K; Niiyama, K; Takahashi, H; Kumagai, U; Urakawa, Y; Nagasawa, Y; Ihara, M; Nishikibe, M; Ishikawa, K Linear peptide ETA antagonists: rational design and practical derivatization of N-terminal amino- and imino-carbonylated tripeptide derivatives Bioorg Med Chem Lett5:1395-1400 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_PIG | Endothelin receptor ET-A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48707.29 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_65803 |
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| Residue: | 427 |
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| Sequence: | METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERS
SHKDSIN
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| BDBM50284699 |
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| n/a |
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| Name | BDBM50284699 |
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| Synonyms: | 2-{3-(1H-Indol-3-yl)-2-[4-methyl-2-(3-methyl-butyrylamino)-pentanoylamino]-propionylamino}-succinic acid | CHEMBL281963 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H36N4O7 |
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| Mol. Mass. | 516.5866 |
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| SMILES | CC(C)C[C@H](NC(=O)CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(O)=O)C(O)=O |
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| Structure | 
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