| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50284880 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_141773 |
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| IC50 | 9±n/a nM |
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| Citation |  Grisonl, S; Huon, C; Peyronel, JF 4,4-Diphenyl-7-perhydrothiapyrano[3,4-c]pyrrolone, a new series of substance P receptors antagonists Bioorg Med Chem Lett5:1591-1594 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50284880 |
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| n/a |
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| Name | BDBM50284880 |
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| Synonyms: | 2-[1-Imino-2-(2-methoxy-phenyl)-ethyl]-4,4-diphenyl-hexahydro-thiopyrano[3,4-c]pyrrol-7-one | CHEMBL288371 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H28N2O2S |
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| Mol. Mass. | 456.599 |
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| SMILES | COc1ccccc1CC(=N)N1CC2C(C1)C(SCC2=O)(c1ccccc1)c1ccccc1 |
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| Structure | 
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