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Reaction Details
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TargetLeukocyte elastase
LigandBDBM50285286
Substrate/Competitorn/a
Meas. Tech.ChEMBL_86286
Ki 0.070±n/a nM
Citation Desai RCDunlap RPFarrell RPFerguson EFranke CAGordon RHlasta DJTalomie TG Alkoxy substituted benzisothiazolone (BIT) derivatives: potent inhibitors of human leukocyte elastase Bioorg Med Chem Lett 5:105-109 (1995)    Article
More Info.:Get all data from this article,  Assay Method
 
Leukocyte elastase
Name:Leukocyte elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50285286
n/a
NameBDBM50285286
Synonyms:2,6-Dichloro-3-(2-morpholin-4-yl-ethoxy)-benzoic acid 4,6-diethoxy-1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethyl ester | CHEMBL430157
TypeSmall organic molecule
Emp. Form.C25H28Cl2N2O9S
Mol. Mass.603.469
SMILESCCOc1cc2c(C(=O)N(COC(=O)c3c(Cl)ccc(OCCN4CCOCC4)c3Cl)S2(=O)=O)c(OCC)c1
Structure
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