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Reaction Details
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TargetLeukocyte elastase
LigandBDBM50285288
Substrate/Competitorn/a
Meas. Tech.ChEMBL_86286
Ki 0.47±n/a nM
Citation Desai RCDunlap RPFarrell RPFerguson EFranke CAGordon RHlasta DJTalomie TG Alkoxy substituted benzisothiazolone (BIT) derivatives: potent inhibitors of human leukocyte elastase Bioorg Med Chem Lett 5:105-109 (1995)    Article
More Info.:Get all data from this article,  Assay Method
 
Leukocyte elastase
Name:Leukocyte elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50285288
n/a
NameBDBM50285288
Synonyms:2,6-Dichloro-benzoic acid 6-methoxy-1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethyl ester | CHEMBL274347
TypeSmall organic molecule
Emp. Form.C16H11Cl2NO6S
Mol. Mass.416.233
SMILESCOc1ccc2C(=O)N(COC(=O)c3c(Cl)cccc3Cl)S(=O)(=O)c2c1
Structure
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