| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sterol O-acyltransferase 1 |
|---|
| Ligand | BDBM50285430 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_28031 |
|---|
| IC50 | 90±n/a nM |
|---|
| Citation |  Wilde, RG; Klaczkiewicz, JD; Billheimer, JT; Wexler, RR; Gillies, PJ Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: heterocyclic bioisosteres for the urea group in DuP 128 Bioorg Med Chem Lett5:177-180 (1995) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sterol O-acyltransferase 1 |
|---|
| Name: | Sterol O-acyltransferase 1 |
|---|
| Synonyms: | ACAT-1 | Acact | Acetoacetyl-CoA thiolase | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-coenzyme A:cholesterol acyltransferase 1 | Cholesterol acyltransferase 1 | SOAT1_MOUSE | Soat1 | Sterol O-acyltransferase 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 63818.83 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_90523 |
|---|
| Residue: | 540 |
|---|
| Sequence: | MSLRNRLSKSGENPEQDEAQKNFMDTYRNGHITMKQLIAKKRLLAAEAEELKPLFMKEVG
CHFDDFVTNLIEKSASLDNGGCALTTFSILEEMKKNHRAKDLRAPPEQGKIFISRQSLLD
ELFEVDHIRTIYHMFIALLILFVLSTIVVDYIDEGRLVLEFNLLAYAFGKFPTVIWTWWA
MFLSTLSIPYFLFQRWAHGYSKSSHPLIYSLVHGLLFLVFQLGVLGFVPTYVVLAYTLPP
ASRFILILEQIRLIMKAHSFVRENIPRVLNAAKEKSSKDPLPTVNQYLYFLFAPTLIYRD
NYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSI
LPGVLILFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYY
YVYKDLLWFFSKRFKSAAMLAVFALSAVVHEYALAICLSYFYPVLFVLFMFFGMAFNFIV
NDSRKRPIWNIMVWASLFLGYGLILCFYSQEWYARQHCPLKNPTFLDYVRPRTWTCRYVF
|
|
|
|---|
| BDBM50285430 |
|---|
| n/a |
|---|
| Name | BDBM50285430 |
|---|
| Synonyms: | Benzooxazol-2-yl-{5-[4,5-bis-(4-dimethylamino-phenyl)-1H-imidazol-2-ylsulfanyl]-pentyl}-amine | CHEMBL50855 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H36N6OS |
|---|
| Mol. Mass. | 540.722 |
|---|
| SMILES | CN(C)c1ccc(cc1)-c1nc(SCCCCCNc2nc3ccccc3o2)[nH]c1-c1ccc(cc1)N(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
