| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50285549 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_202105 |
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| IC50 | 767±n/a nM |
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| Citation |  Harris, GH; Dufresne, C; Joshua, H; Koch, LA; Zink, DL; Salmon, PM; Göklen, KE; Kurtz, MM; Rew, DJ; Bergstrom, JD; Wilson, KE Isolation, structure determination and squalene synthase activity of L-731,120 and L-731,128, alkyl citrate analogs of zaragozic acids A and B Bioorg Med Chem Lett5:2403-2408 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48109.41 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1336736 |
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| Residue: | 416 |
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| Sequence: | MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQA
LDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRV
VLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVG
IGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYV
KKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAK
QLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
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| BDBM50285549 |
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| n/a |
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| Name | BDBM50285549 |
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| Synonyms: | 3-Carboxy-2-((E)-6,8-dimethyl-11-phenyl-undec-10-enyl)-3-hydroxy-pentanedioic acid | CHEMBL78492 | L-731128 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H36O7 |
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| Mol. Mass. | 448.5491 |
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| SMILES | CC(CCCCCC(C(O)=O)C(O)(CC(O)=O)C(O)=O)CC(C)C\C=C\c1ccccc1 |
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| Structure | 
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