Reaction Details |
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Target | Platelet-activating factor receptor |
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Ligand | BDBM50286041 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_155151 |
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Ki | 4000±n/a nM |
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Citation | Sheppard, GS; Davidsen, SK; Carrera, GM; Pireh, D; Holms, JH; Heyman, HR; Steinman, DH; Curtin, ML; Conway, RG; Rhein, DA; Albert, DH; Tapang, P; Magoc, TJ; Summers, JB Synthesis and evaluation of water soluble indole pyrrolothiazole paf antagonists Bioorg Med Chem Lett5:2913-2918 (1995) Article |
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More Info.: | Get all data from this article, Assay Method |
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Platelet-activating factor receptor |
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Name: | Platelet-activating factor receptor |
Synonyms: | PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor |
Type: | Protein |
Mol. Mass.: | 39005.63 |
Organism: | Cavia porcellus |
Description: | n/a |
Residue: | 342 |
Sequence: | MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLT
VADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVK
YPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKG
SKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAV
FVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
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BDBM50286041 |
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n/a |
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Name | BDBM50286041 |
Synonyms: | 5-{(R)-7-[1-Dimethylcarbamoyl-6-(4-fluoro-phenyl)-1H-indole-3-carbonyl]-1H-pyrrolo[1,2-c]thiazol-3-yl}-1-methyl-1,2-dihydro-pyridinium; iodide | CHEMBL99395 |
Type | Small organic molecule |
Emp. Form. | C30H28FN4O2S |
Mol. Mass. | 527.632 |
SMILES | CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)C2=C[NH+](C)CC=C2)c2ccc(cc12)-c1ccc(F)cc1 |c:25,t:20| |
Structure |
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