| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-1 |
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| Ligand | BDBM50176519 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_90976 |
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| Ki | 15±n/a nM |
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| Citation |  Prasad, CV; Prouty, CP; Hoyer, D; Ross, TM; Salvino, JM; Awad, M; Graybill, TL; Schmidt, SJ; Osifo, IK; Dolle, RE; Helaszek, CT; Miller, RE; Ator, MA Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme Bioorg Med Chem Lett5:315-318 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-1 |
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| Name: | Caspase-1 |
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| Synonyms: | CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme |
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| Type: | Enzyme |
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| Mol. Mass.: | 45154.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29466 |
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| Residue: | 404 |
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| Sequence: | MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
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| BDBM50176519 |
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| n/a |
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| Name | BDBM50176519 |
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| Synonyms: | (S)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-butyric acid | CHEMBL320954 | Z-VAD-CHO |
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| Type | Small organic molecule |
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| Emp. Form. | C20H27N3O7 |
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| Mol. Mass. | 421.4443 |
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| SMILES | CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C=O |
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| Structure | 
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