| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50286305 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_219643 |
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| Ki | 0.800000±n/a nM |
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| Citation |  Subramanyam, C; Bell, MR; Ferguson, E; Gordon, RG; Dunlap, RP; Franke, C; Mura, AJ Inhibitors of human leukocyte elastase. 2.1 synthesis and sar of benzisothiazolinylmethyl aryl ethers Bioorg Med Chem Lett5:319-324 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50286305 |
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| n/a |
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| Name | BDBM50286305 |
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| Synonyms: | 2-[2-Chloro-4-(morpholine-4-sulfonyl)-phenoxymethyl]-4-isopropyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one | CHEMBL109234 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23ClN2O7S2 |
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| Mol. Mass. | 515 |
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| SMILES | CC(C)c1cccc2c1C(=O)N(COc1ccc(cc1Cl)S(=O)(=O)N1CCOCC1)S2(=O)=O |
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| Structure | 
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