| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal acid lipase/cholesteryl ester hydrolase |
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| Ligand | BDBM50287472 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_154781 |
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| IC50 | 10000±n/a nM |
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| Citation |  David, B; Schuber, F Synthesis of α-difluoro and α-difluoro-β-trifluoroketo-derivatives as potential inhibitors for Cholesterol Ester Hydrolase Bioorg Med Chem Lett6:1673-1676 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal acid lipase/cholesteryl ester hydrolase |
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| Name: | Lysosomal acid lipase/cholesteryl ester hydrolase |
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| Synonyms: | LICH_HUMAN | LIPA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45422.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_633497 |
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| Residue: | 399 |
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| Sequence: | MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYI
LCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNS
RGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIG
FIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFL
KWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAV
KFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQI
TNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ
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| BDBM50287472 |
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| n/a |
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| Name | BDBM50287472 |
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| Synonyms: | 1-((S)-10,13-Dimethyl-17-octyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl)-3,3,4,4,4-pentafluoro-butan-2-one | CHEMBL3137812 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H49F5O |
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| Mol. Mass. | 532.7122 |
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| SMILES | [H][C@@]12CCC(CCCCCCCC)C1(C)CC[C@@]1([H])[C@@]2([H])CCC2C[C@@H](CC(=O)C(F)(F)C(F)(F)F)CCC12C |
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| Structure | 
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