| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C gamma type |
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| Ligand | BDBM3199 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_153154 (CHEMBL761877) |
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| IC50 | 40±n/a nM |
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| Citation |  Jr., GE; Defauw, JM; Lampe, JW; Darges, JW; Kalter, K Potent and selective PKC inhibitory 5-membered ring analogs of balanol with replacement of the carboxamide moiety Bioorg Med Chem Lett6:1759-1764 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C gamma type |
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| Name: | Protein kinase C gamma type |
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| Synonyms: | KPCG_HUMAN | PKC gamma | PKC-gamma | PKCG | PRKCG | Protein kinase C gamma | Protein kinase C gamma type | Protein kinase C, PKC; classical/novel | Protein kinase C, gamma |
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| Type: | Enzyme |
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| Mol. Mass.: | 78458.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells
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| Residue: | 697 |
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| Sequence: | MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIG
KQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSL
LYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEA
RNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRL
SVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQ
KFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKG
SFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQL
HSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRD
LKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWS
FGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGS
GPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRL
VLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM
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| BDBM3199 |
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| n/a |
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| Name | BDBM3199 |
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| Synonyms: | (+-)-anti-2-[[2,6-Dihydroxy-4-[[[2-(4-hydroxybenzyl)cyclopentyl]oxy]carbonyl]phenyl]carbonyl]-3-hydroxybenzoic acid | 2-{[2,6-dihydroxy-4-({[(1R,2S)-2-[(4-hydroxyphenyl)methyl]cyclopentyl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid | Acyclic Balanol Analog 29b |
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| Type | Small organic molecule |
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| Emp. Form. | C27H24O9 |
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| Mol. Mass. | 492.4741 |
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| SMILES | OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1Cc1ccc(O)cc1 |r| |
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| Structure | 
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