| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin D |
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| Ligand | BDBM50287742 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_45186 |
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| IC50 | 1860±n/a nM |
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| Citation |  Whitesitt, CA; Simon, RL; Reel, JK; Sigmund, SK; Phillips, ML; Shadle, JK; Heinz, LJ; Koppel, GA; Hunden, DC; Lifer, SL; Berry, D; Ray, J; Little, SP; Liu, X; Marshall, WS; Panetta, JA Synthesis and structure-activity relationships of benzophenones as inhibitors of cathepsin D Bioorg Med Chem Lett6:2157-2162 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin D |
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| Name: | Cathepsin D |
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| Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 44551.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
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| Residue: | 412 |
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| Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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| BDBM50287742 |
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| n/a |
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| Name | BDBM50287742 |
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| Synonyms: | 5-[1-[4-(4-Acetyl-3-methoxy-2-propyl-benzyloxy)-phenyl]-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one | CHEMBL67585 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23NO4S2 |
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| Mol. Mass. | 441.563 |
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| SMILES | CCCc1c(COc2ccc(C=C3SC(S)=NC3=O)cc2)ccc(C(C)=O)c1OC |w:11.10,c:15| |
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| Structure | 
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