Reaction Details |
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Target | Cathepsin D |
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Ligand | BDBM50084636 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_45186 |
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IC50 | 210±n/a nM |
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Citation | Whitesitt, CA; Simon, RL; Reel, JK; Sigmund, SK; Phillips, ML; Shadle, JK; Heinz, LJ; Koppel, GA; Hunden, DC; Lifer, SL; Berry, D; Ray, J; Little, SP; Liu, X; Marshall, WS; Panetta, JA Synthesis and structure-activity relationships of benzophenones as inhibitors of cathepsin D Bioorg Med Chem Lett6:2157-2162 (1996) Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin D |
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Name: | Cathepsin D |
Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
Type: | Enzyme |
Mol. Mass.: | 44551.72 |
Organism: | Homo sapiens (Human) |
Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
Residue: | 412 |
Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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BDBM50084636 |
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n/a |
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Name | BDBM50084636 |
Synonyms: | 5-[1-[4-(4-Benzoyl-3-hydroxy-2-propyl-benzyloxy)-phenyl]-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one | 5-[4-(4-Benzoyl-3-hydroxy-2-propyl-benzyloxy)-benzylidene]-2-thioxo-thiazolidin-4-one | CHEMBL69980 |
Type | Small organic molecule |
Emp. Form. | C27H23NO4S2 |
Mol. Mass. | 489.606 |
SMILES | CCCc1c(O)c(ccc1COc1ccc(C=C2SC(S)=NC2=O)cc1)C(=O)c1ccccc1 |w:16.16,c:21| |
Structure |
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