| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50288013 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_65464 (CHEMBL682104) |
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| IC50 | 2.8±n/a nM |
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| Citation |  Chan, MF; Raju, B; Kois, A; Castillo, RS; Verner, EJ; Wu, C; Hwang, E; Okun, I; Stavros, F; Balaji, VN Halogen substitution at the isoxazole ring enhances the activity of N-(isoxazolyl)sulfonamide endothelin antagonists Bioorg Med Chem Lett6:2393-2398 (1996) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50288013 |
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| n/a |
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| Name | BDBM50288013 |
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| Synonyms: | 5-Bromo-N-(4-bromo-3-methyl-isoxazol-5-yl)-2-ethyl-benzenesulfonamide | CHEMBL309692 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12Br2N2O3S |
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| Mol. Mass. | 424.108 |
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| SMILES | CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br |
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| Structure | 
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