Reaction Details |
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Target | Endothelin receptor type B |
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Ligand | BDBM50288041 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_63526 |
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IC50 | 3800±n/a nM |
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Citation | Chan, MF; Raju, B; Kois, A; Castillo, RS; Verner, EJ; Wu, C; Hwang, E; Okun, I; Stavros, F; Balaji, VN Halogen substitution at the isoxazole ring enhances the activity of N-(isoxazolyl)sulfonamide endothelin antagonists Bioorg Med Chem Lett6:2393-2398 (1996) Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin receptor type B |
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Name: | Endothelin receptor type B |
Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 49664.00 |
Organism: | Homo sapiens (Human) |
Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
Residue: | 442 |
Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
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BDBM50288041 |
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n/a |
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Name | BDBM50288041 |
Synonyms: | CHEMBL79080 | N-(4-Bromo-3-methyl-isoxazol-5-yl)-4-nitro-benzenesulfonamide |
Type | Small organic molecule |
Emp. Form. | C10H8BrN3O5S |
Mol. Mass. | 362.157 |
SMILES | Cc1[n-][o+]c(NS(=O)(=O)c2ccc(cc2)[N+]([O-])=O)c1Br |
Structure |
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