Reaction Details | |||
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Target | 5-hydroxytryptamine receptor 3A | ||
Ligand | BDBM50288283 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_3408 (CHEMBL620722) | ||
Ki | 0.075000±n/a nM | ||
Citation | Paulis, Td; Trivedi, BL; Zhang, ZJ; Schmidt, DE; Ebert, MH; Hewlett, WA (S)-4-amino-5-chloro-3-iodo-2-methoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (TRIZAC), a high-affinity ligand for the 5-HT-3 receptor Bioorg Med Chem Lett6:2657-2662 (1996) Article | ||
More Info.: | Get all data from this article, Assay Method | ||
5-hydroxytryptamine receptor 3A | |||
Name: | 5-hydroxytryptamine receptor 3A | ||
Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 55428.70 | ||
Organism: | RAT | ||
Description: | 5-HT3 HTR3A RAT::P35563 | ||
Residue: | 483 | ||
Sequence: |
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BDBM50288283 | |||
n/a | |||
Name | BDBM50288283 | ||
Synonyms: | 4-Amino-N-(S)-1-aza-bicyclo[2.2.2]oct-3-yl-5-chloro-3-iodo-2-methoxy-benzamide | CHEMBL314164 | ||
Type | Small organic molecule | ||
Emp. Form. | C15H19ClIN3O2 | ||
Mol. Mass. | 435.688 | ||
SMILES | COc1c(I)c(N)c(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 |wU:14.14,(11.77,-27.01,;11.77,-25.48,;10.45,-24.71,;9.1,-25.48,;9.1,-27.01,;7.78,-24.71,;6.45,-25.48,;7.78,-23.17,;6.45,-22.4,;9.1,-22.4,;10.45,-23.17,;11.77,-22.4,;11.77,-20.86,;13.1,-23.17,;14.43,-22.4,;15.77,-23.18,;17.09,-22.42,;17.11,-20.88,;15.77,-20.1,;14.43,-20.86,;15.24,-22.25,;16.38,-21.1,)| | ||
Structure |