Reaction Details |
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Target | cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma |
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Ligand | BDBM3149 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_161742 (CHEMBL769032) |
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IC50 | 80±n/a nM |
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Citation | Hu, H; Hollinshead, SP; Hall, SE; Kalter, K; Ballas, LM Synthesis and protein kinase C inhibitory activities of indane analogs of balanol Bioorg Med Chem Lett6:973-978 (1996) Article |
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More Info.: | Get all data from this article, Assay Method |
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cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma |
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Name: | cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma |
Synonyms: | cAMP-dependent protein kinase (PKA) |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 217489 |
Components: | This complex has 3 components. |
Component 1 |
Name: | cAMP-dependent protein kinase catalytic subunit beta |
Synonyms: | KAPCB_HUMAN | PKA C-beta | PKAC-beta | PRKACB | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase beta-1 catalytic subunit | cAMP-dependent protein kinase catalytic subunit beta |
Type: | PROTEIN |
Mol. Mass.: | 40631.25 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_586348 |
Residue: | 351 |
Sequence: | MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML
VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT
TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
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Component 2 |
Name: | cAMP-dependent protein kinase catalytic subunit alpha |
Synonyms: | KAPCA_HUMAN | PKA C-alpha | PKACA | PRKACA | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase, alpha-catalytic subunit |
Type: | Enzyme Catalytic Subunit |
Mol. Mass.: | 40598.73 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 351 |
Sequence: | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVML
VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
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Component 3 |
Name: | cAMP-dependent protein kinase catalytic subunit gamma |
Synonyms: | KAPCG_HUMAN | PKA C-gamma | PRKACG | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic subunit gamma |
Type: | PROTEIN |
Mol. Mass.: | 40442.03 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_104720 |
Residue: | 351 |
Sequence: | MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML
VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV
MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY
LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY
ADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFAT
TSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF
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BDBM3149 |
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n/a |
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Name | BDBM3149 |
Synonyms: | 2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid | Acyclic Balanol Analog (-)-1 | Balanol analog 1 | Balanol, 1 | CHEMBL60254 |
Type | Small organic molecule |
Emp. Form. | C28H26N2O10 |
Mol. Mass. | 550.5134 |
SMILES | OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r| |
Structure |
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