| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-1 adrenergic receptor |
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| Ligand | BDBM25756 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_216176 (CHEMBL820268) |
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| IC50 | 320±n/a nM |
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| Citation |  Iseki, K; Oishi, S; Sasai, H; Shibasaki, M SYNTHESIS AND BIOLOGICAL EVALUATION OF A FLUORINATED ANALOG OF THE β-ADRENERGIC BLOCKING AGENT, METOPROLOL Bioorg Med Chem Lett7:1273-1274 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-1 adrenergic receptor |
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| Name: | Beta-1 adrenergic receptor |
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| Synonyms: | ADRB1 | Adrenergic receptor | adrenergic Beta1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50540.48 |
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| Organism: | GUINEA PIG |
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| Description: | adrenergic Beta1 ADRB1 GUINEA PIG::B0FL73 |
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| Residue: | 467 |
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| Sequence: | MGAGVLALGASEPCNLSSTAPLPDGAATAARLLVPASPPASLLPPTSEGSEPLSPQWTAG
MGLLMVLIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARVLVC
TVWAISALVSFLPILMHWWRAEGDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPGRPPSPVPSPTPGSPRAATDPLANGRTSKRR
PSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANS
AFNPIIYCRSPDFRKAFQRLLCCARRAARRRHTAHGGRPRASGCLARSGPPPSPGAASDE
DEDAVGAAPPARLLEPWAGCNGGAATADSDWSLDEPGRAGFASESKV
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| BDBM25756 |
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| n/a |
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| Name | BDBM25756 |
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| Synonyms: | (2R,3R)-2,3-dihydroxysuccinic acid;1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol | Betalok | CHEMBL13 | Metoprolol | Spesicor | Spesikor | metoprolol tartrate | {2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl}(propan-2-yl)amine |
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| Type | Small organic molecule |
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| Emp. Form. | C15H25NO3 |
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| Mol. Mass. | 267.3639 |
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| SMILES | COCCc1ccc(OCC(O)CNC(C)C)cc1 |
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| Structure | 
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