| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
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| Ligand | BDBM16314 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_31798 |
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| IC50 | 16±n/a nM |
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| Citation |  Aotsuka, T; Abe, N; Fukushima, K; Ashizawa, N; Yoshida, M Benzothiazol-2-ylcarboxylic acids with diverse spacers: A novel class of potent, orally active aldose reductase inhibitors Bioorg Med Chem Lett7:1677-1682 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 |
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| Name: | Aldo-keto reductase family 1 member B1 |
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| Synonyms: | AKR1B1 | ALDR_PIG | ALR2 | AR | Aldose reductase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35865.31 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_502637 |
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| Residue: | 316 |
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| Sequence: | MASHLVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQ
EKLQGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGK
DPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKP
AVNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
YNKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCA
LMSCASHKDYPFHEEY
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| BDBM16314 |
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| n/a |
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| Name | BDBM16314 |
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| Synonyms: | 2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-N-methylmethanethioamido}acetic acid | Alredase | CHEMBL436 | N-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]carbonothioyl}-N-methylglycine | Tolrestat |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14F3NO3S |
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| Mol. Mass. | 357.347 |
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| SMILES | COc1ccc2c(cccc2c1C(F)(F)F)C(=S)N(C)CC(O)=O |
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| Structure | 
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