| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin receptor type B |
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| Ligand | BDBM50289934 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_63682 |
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| IC50 | >100000±n/a nM |
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| Citation |  Raju, B; Wu, C; Castillo, R; Okun, I; Stavros, F; Chan, MF 2-Aryloxycarbonylthiophene-3-sulfonamides: Highly potent and etA selective endothelin receptor antagonists Bioorg Med Chem Lett7:2093-2098 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin receptor type B |
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| Name: | Endothelin receptor type B |
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| Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49664.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
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| Residue: | 442 |
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| Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
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| BDBM50289934 |
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| n/a |
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| Name | BDBM50289934 |
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| Synonyms: | 3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid methyl ester | CHEMBL63169 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H9ClN2O5S2 |
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| Mol. Mass. | 336.772 |
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| SMILES | COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl |
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| Structure | 
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