Ki Summary

Reaction Details

Report a problem with these data

Target

5-hydroxytryptamine receptor 4

Ligand

BDBM50289988

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_201190 (CHEMBL801209)

EC50

>10000±n/a nM

Citation

Becker, DP; Nosal, R; Villamil, CI; Gullikson, G; Moummi, C; Yang, DC; Flynn, DL Serotonin 5-HT₄ agonist activity of a series of meso-azanoradamantane benzamides Bioorg Med Chem Lett7:2149-2154 (1997) Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 4

Name:

5-hydroxytryptamine receptor 4

Synonyms:

5-HT-4 | 5-HT4 | 5-HT4L | 5-HT4S | 5-hydroxytryptamine receptor 4 | 5HT4R_RAT | Htr4 | Serotonin (5-HT) receptor | Serotonin 4 (5-HT4) receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

46117.31

Organism:

RAT

Description:

5-HT4 HTR4 RAT::Q62758

Residue:

406

Sequence:

MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSN
STFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRP
QTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRD
TVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS

BDBM50289988

n/a

Name

BDBM50289988

Synonyms:

4-Acetylamino-N-(3-aza-tricyclo[3.3.1.0*3,7*]non-9-yl)-5-chloro-2-methoxy-benzamide | CHEMBL303877

Type

Small organic molecule

Emp. Form.

C18H22ClN3O3

Mol. Mass.

363.839

SMILES

COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC1C2CC3CC1CN3C2 |TLB:18:17:22:19.20,18:19:17.16.24:22,THB:15:16:22:19.20,(22.01,-9.95,;22.01,-8.41,;20.68,-7.64,;19.35,-8.41,;18.02,-7.64,;16.69,-8.41,;15.36,-7.64,;14.02,-8.41,;15.36,-6.1,;18.02,-6.1,;16.69,-5.33,;19.35,-5.33,;20.68,-6.1,;22.01,-5.32,;22.01,-3.78,;23.36,-6.09,;24.69,-5.32,;26.51,-5.19,;27.89,-5.79,;28.94,-4.56,;27.53,-4.85,;25.99,-4.04,;26.23,-2.71,;27.63,-2.4,;26.55,-3.6,)|

Structure