Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50290520 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_79974 |
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Ki | 0.700000±n/a nM |
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Citation | Choy, N; Choi, Hi; Jung, WH; Kim, CR; Yoon, H; Kim, SC; Lee, TG; Koh, JS Synthesis of irreversible HIV-1 protease inhibitors containing sulfonamide and sulfone as amide bond isosteres Bioorg Med Chem Lett7:2635-2638 (1997) Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50290520 |
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n/a |
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Name | BDBM50290520 |
Synonyms: | ((R)-1-{(S)-1-[(2R,3S)-3-(2-tert-Butylsulfamoyl-ethyl)-oxiranyl]-2-phenyl-ethylcarbamoyl}-2-methanesulfonyl-2-methyl-propyl)-carbamic acid benzyl ester | CHEMBL328956 |
Type | Small organic molecule |
Emp. Form. | C30H43N3O8S2 |
Mol. Mass. | 637.808 |
SMILES | CC(C)(C)NS(=O)(=O)CC[C@@H]1O[C@@H]1[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)(C)S(C)(=O)=O |
Structure |
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