| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM50290523 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_79974 |
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| Ki | 3.1±n/a nM |
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| Citation |  Choy, N; Choi, Hi; Jung, WH; Kim, CR; Yoon, H; Kim, SC; Lee, TG; Koh, JS Synthesis of irreversible HIV-1 protease inhibitors containing sulfonamide and sulfone as amide bond isosteres Bioorg Med Chem Lett7:2635-2638 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
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| BDBM50290523 |
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| n/a |
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| Name | BDBM50290523 |
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| Synonyms: | CHEMBL327222 | Thiophene-2-carboxylic acid [(R)-1-((S)-1-{(2R,3S)-3-[2-(ethyl-isopropyl-sulfamoyl)-ethyl]-oxiranyl}-2-phenyl-ethylcarbamoyl)-2-methanesulfonyl-2-methyl-propyl]-amide |
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| Type | Small organic molecule |
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| Emp. Form. | C28H41N3O7S3 |
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| Mol. Mass. | 627.836 |
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| SMILES | CCN(C(C)C)S(=O)(=O)CC[C@@H]1O[C@@H]1[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)c1cccs1)C(C)(C)S(C)(=O)=O |
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| Structure | 
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