| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50290928 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1233 |
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| Ki | 652±n/a nM |
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| Citation |  Sonesson, C; Wikström, H; Smith, MW; Svensson, K; Carlsson, A; Waters, N Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity. Bioorg Med Chem Lett7:241-246 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46445.29 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Binding assays were performed using rat hippocampal membranes. |
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| Residue: | 422 |
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| Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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| BDBM50290928 |
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| n/a |
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| Name | BDBM50290928 |
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| Synonyms: | CHEMBL79812 | Trifluoro-methanesulfonic acid 3-(1-propyl-pyrrolidin-3-yl)-phenyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C14H18F3NO3S |
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| Mol. Mass. | 337.358 |
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| SMILES | CCCN1CCC(C1)c1cccc(OS(=O)(=O)C(F)(F)F)c1 |
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| Structure | 
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