Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50290934 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1233 (CHEMBL615875) |
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IC50 | >1000±n/a nM |
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Citation | Sonesson, C; Wikström, H; Smith, MW; Svensson, K; Carlsson, A; Waters, N Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity. Bioorg Med Chem Lett7:241-246 (1997) Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50290934 |
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n/a |
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Name | BDBM50290934 |
Synonyms: | 3-(1-Propyl-pyrrolidin-3-yl)-pyridine | CHEMBL311378 |
Type | Small organic molecule |
Emp. Form. | C12H18N2 |
Mol. Mass. | 190.2847 |
SMILES | CCCN1CCC(C1)c1cccnc1 |
Structure |
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