Ki Summary

Reaction Details

Report a problem with these data

Target

Calpain-1 catalytic subunit

Ligand

BDBM50287391

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_43661

IC50

25±n/a nM

Citation

Chatterjee, S; Senadhi, S; Bozyczko-Coyne, D; Siman, R; Mallamo, JP Nonpeptidic inhibitors of recombinant human calpain I Bioorg Med Chem Lett7:287-290 (1997) Article

More Info.:

Get all data from this article, Assay Method

Calpain-1 catalytic subunit

Name:

Calpain-1 catalytic subunit

Synonyms:

Type:

Protein

Mol. Mass.:

81880.51

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

714

Sequence:

MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA

BDBM50287391

n/a

Name

BDBM50287391

Synonyms:

(R)-4-Methyl-2-[2-oxo-2-(9H-xanthen-9-yl)-ethyl]-pentanoic acid ((S)-1-formyl-3-methyl-butyl)-amide | CHEMBL42716

Type

Small organic molecule

Emp. Form.

C27H33NO4

Mol. Mass.

435.5552

SMILES

CC(C)C[C@H](NC(=O)[C@H](CC(C)C)CC(=O)C1c2ccccc2Oc2ccccc12)C=O

Structure