| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50291498 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_65629 |
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| IC50 | 73±n/a nM |
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| Citation |  Raju, B; Okun, I; Stavros, F; Chan, MF Amide bond surrogates: A study in thiophenesulfonamide based endothelin receptor antagonists Bioorg Med Chem Lett7:939-944 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50291498 |
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| n/a |
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| Name | BDBM50291498 |
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| Synonyms: | 3-{2-[6-(Tetrahydro-pyran-4-yloxymethyl)-benzo[1,3]dioxol-5-yl]-vinyl}-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide | CHEMBL176675 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23BrN2O7S2 |
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| Mol. Mass. | 583.472 |
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| SMILES | Cc1noc(NS(=O)(=O)c2sccc2\C=C\c2cc3OCOc3cc2COC2CCOCC2)c1Br |
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| Structure | 
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