| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin receptor type B |
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| Ligand | BDBM50291500 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_63711 |
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| IC50 | 12450±n/a nM |
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| Citation |  Raju, B; Okun, I; Stavros, F; Chan, MF Amide bond surrogates: A study in thiophenesulfonamide based endothelin receptor antagonists Bioorg Med Chem Lett7:939-944 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin receptor type B |
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| Name: | Endothelin receptor type B |
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| Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49664.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
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| Residue: | 442 |
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| Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
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| BDBM50291500 |
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| n/a |
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| Name | BDBM50291500 |
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| Synonyms: | 3-[2-(6-Methyl-benzo[1,3]dioxol-5-yl)-ethyl]-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide | CHEMBL366378 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17BrN2O5S2 |
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| Mol. Mass. | 485.372 |
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| SMILES | Cc1noc(NS(=O)(=O)c2sccc2CCc2cc3OCOc3cc2C)c1Br |
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| Structure | 
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